Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.

Activation of the inositol (1,4,5)-triphosphate calcium gate receptor is required for HIV-1 Gag release.

The structural precursor polyprotein, Gag, encoded by all retroviruses, including the human immunodeficiency virus type 1 (HIV-1), is necessary and sufficient for the assembly and release of particles that morphologically resemble immature virus particles. Previous studies have shown that the addition of Ca(2+) to cells expressing Gag enhances virus particle production. However, no specific cel...

Stores in Peritoneal Macrophages and Release of Calcium from Intracellular 1,4,5-Trisphosphate Binding to Its Receptors Cyclosporin A Inhibits Inositol

Transient release of calcium from inositol 1,4,5-trisphosphate-specific stores regulates mouse preimplantation development.

Inositol 1,4,5-trisphosphate can regulate growth and differentiation by modulating the release of intracellular Ca2+ in a variety of cellular systems, and it is involved in oocyte activation. Recent studies suggest that mammalian preimplantation development may also be regulated by the release of Ca2+ from intracellular stores. The rate of cavitation and cell division was accelerated after a tr...

The inositol 1,4,5-trisphosphate receptor--transcriptional regulation and modulation by phosphorylation.

Inositol 1,4,5-trisphosphate receptors (IP3Rs) are intracellular membrane calcium channels essential for the release of calcium from intracellular stores. They form pathways for Ca2+ release that amplifies signals transmitted via plasma membrane receptors and so mediate a large array of calcium-regulated signal transduction events, from control of gene expression, through regulation of cell pro...

Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptor.

Stimulation of B-cell antigen receptor (BCR) induces a rapid increase in cytoplasmic free calcium due to its release from intracellular stores and influx from the extracellular environment. Inositol 1,4,5-trisphosphate receptors (IP3Rs) are ligand-gated channels that release intracellular calcium stores in response to the second messenger, inositol 1,4,5-trisphosphate. Most hematopoietic cells,...